Abolishing CDK4/six kinase activity and subsequent reactivation of Rb in these tumors has long been shown to inhibit tumor initiation and advancement. Below we will explain LEE011- an orally bioavailable, selective tiny molecule inhibitor of CDK4/6 kinases. LEE011 inhibits CDK4/6 kinase action with nM IC50 and is highly selective for https://trumand824qwb4.blog5star.com/profile