Chemotherapy was potentiated by E7449 and single agent had major antitumor exercise in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, very likely through TNKS inhibition. In keeping with this risk, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and significantly altered expression of Wnt https://isorhamnetin-3-o-glucosid76543.mybloglicious.com/50439149/about-apigenin