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There is a launch of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to reduce afferent pain transmission and create analgesia. Hence, medications like clonidine that target alpha-two receptors can impact the transmission of soreness. For those who get dizzy when standing: https://johnb050qhx5.wikififfi.com/user

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